human pbmcs — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T15371	Gardiquimod		TLR , HIV Protease
	Gardiquimod is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7. Gardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells...		TLR , HIV Protease
T12079	ML604440		Proteasome
	ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.		Proteasome
T11465	Lenacapavir	GS-6207	Others , HIV Protease
	Lenacapavir (GS-6207) is a potent capsid-targeting inhibitor of HIV replication. Lenacapavir shows anti-HIV activity with an EC50 of 100 pM in MT-4 cells.		Others , HIV Protease
T2384	Pomalidomide	CC-4047	Apoptosis , TNF , Ligand for E3 Ligase , Molecular Glues
	Pomalidomide (CC-4047) inhibits TNF-α release in LPS stimulated human PBMCs (IC50: 13 nM). It is an anti-angiogenic agent and an immunomodulator.		Apoptosis , TNF , Ligand for E3 Ligase , Molecular Glues
T28946	Tenofovir exalidex	Tenofovir,HDP-Tenofovir,CMX-157,CMX157,CMX 157	Antiviral
	Tenofovir exalidex (CMX 157) is a lipid-conjugated acyclic nucleotide analog of Tenofovir, demonstrating efficacy against wild-type and antiretroviral-resistant HIV strains, including those resistant to multiple nucleosi...		Antiviral
T11035	DiABZI STING agonist-1 (Tautomerism)	diABZI STING agonist (Compound 3)	STING
	diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.		STING
T27967	M199
	M199, a novel inhibitor of TLR3/9 activation, induces secretion of IL-6, IL-8 and TNFalpha in human PBMCs.
T27030	CK176	HIV-1 inhibitor-34,HIV-1 inhibitor 34,CK 176,CK-176,HIV-1 inhibitor34
	CK176 is a capsid targeted inhibitor of HIV-1 replication. CK176 shows an 11-fold improvement over I-XW-053 in blocking HIV-1 replication in primary human peripheral blood mononuclear cells (PBMCs).
T83698	Cathelicidin-2 (128-153) (chicken) TFA	Fowlicidin-2 (128-153),CATH-2 (128-153),Myeloid Antimicrobial Peptide 27 (128-153)
	Cathelicidin-2 (CATH-2) (128-153) is a synthetic antimicrobial peptide derived from amino acids 128-153 of chicken CATH-2, demonstrating activity against pathogens such as E. coli, S. aureus, S. enteritidis, and B. globi...
T77851	INX-SM-6
	INX-SM-6, a chemical compound, serves as a targeted delivery vehicle for anti-inflammatory agents and has shown efficacy in suppressing LPS-induced IL-1β production in human PBMCs [1].
TN6054	Norglaucine hydrochloride
	(+)-Norglaucine shows cytotoxic activity toward the tumor cell lines B16-F10 (mouse melanoma), HepG2 (human hepatocellular carcinoma), K562 (human chronic myelocytic leukemia) and HL-60 (human promyelocytic leukemia) and...
T74915	ODN D-SL03
	ODN D-SL03, a class C CpG oligonucleotide, effectively stimulates peripheral blood mononuclear cells (PBMCs) to produce high levels of IFN-α. It activates human B cells, NK cells, and mononuclear cells, elevating the exp...
T83846	HOXB7 (8-25) TFA	Homeobox B7 (8-25)
	HOXB7 (8-25), a peptide fragment derived from homeobox B7 (HOXB7)—a key controller of cell growth and oncogene activator—facilitates antigen presentation when pulsed onto dendritic cells obtained from human peripheral bl...
T79151	TLR8 agonist 6
	Compound A, a potent TLR8 agonist, exhibits an EC50 of 0.052 µM and promotes the production of IL-12p40 in human PBMCs with an EC50 of 0.031 µM. This compound is applicable for research in virus resistance, infection res...
T35929	O-Demethyl Apremilast
	O-Demethyl apremilast is an active metabolite of the phosphodiesterase 4 (PDE4) inhibitor apremilast .1It inhibits the activity of PDE4 isolated from U937 cells and LPS-induced TNF-α production in isolated human peripher...
T81314	Rademikibart	CBP-201
	Rademikibart (CBP-201) is a human monoclonal antibody selective for IL-4Rα, exhibiting strong affinity with a KD of 20.7 pM for human IL-4Rα epitopes, without cross-reactivity to IL-4Rα from other species. It effectively...
T36862	Ganglioside GT1b Mixture (sodium salt)	Ganglioside GT1b Mixture (sodium salt),Ganglioside G1 Mixture
	Ganglioside GT1b is a trisialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit. It binds to the neurotoxins botulinum toxin serotype A (BTxA), BTxA heavy chain, and tetan...
T35672	SMU127
	SMU127 is an agonist of the toll-like receptor 1/2 (TLR1/2) heterodimer.1It induces NF-κB signaling in cells expressing human TLR2 (EC50= 0.55 μM) but not cells expressing human TLR3, -4, -5, -7, or -8 when used at conce...
T83852	EGFRvIII Peptide TFA	PEGFRvIII (9-mer),Epidermal Growth Factor Receptor Variant III Peptide
	EGFRvIII peptide, a synthetic peptide mirroring the EGFRvIII fusion junction—a tumor-specific, perpetually active EGFR variant missing amino acids 6-273 of the wild-type—binds to HLA-A*0201-positive T2 cells under MHC cl...
T35829	CC-90005
	CC-90005 is a potent, selective and orally active inhibitor of protein kinase C-θ (PKC-θ), with an IC50 of 8 nM. CC-90005 shows selectivity for PKC-θ over PKC-δ (IC50=4440 nM). CC-90005 can inhibit T cell activation by I...